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Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder & many other disorders. It is one of the selective serotonin reuptake inhibitors & is marketed in capsules containing 10, 20, or 40 mg of active ingredient or in tablets containing 10 mg. Dosages in the range of 20-60 mg per day are standard, with 80 mg considered a maximum. Eli Lillys Prozac was approved by the FDA on December 27, 1987 & introduced in the US at the beginning of 1988. The drug became very popular, with millions around the world having taken the medication. Fluoxetine has a wide range of published interactions, notably with monoamine oxidase inhibitors. Common side-effects include anxiety, restlessness, trembling, weakness, skin rash, anorgasmia, itching & a decrease in sexual drive. Fluoxetine is eliminated very slowly by the body. The half-life of fluoxetine after a single dose is 2 days & after multiple dosing 4 days.
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